VDR https://www.dataroomapps.net/data-management-made-simple-how-virtual-data-rooms-can-simplify-your-complex-business-processes/ Functions
Virtual Data Rooms are utilized by law firms, CPAs and accounting firms to organize, collect and manage client documentation for audit and tax preparation. Mortgage brokers and banks too utilize vdr for document collection and sharing with clients and third parties. Investment banking processes like IPOs capital raising and M&A can require huge amounts of information sharing that a VDR is well suited to handle.
The VDR undergoes a variety post-translational changes that regulate its function. These modifications include the ligand binding domain, activation function 2(AF-2), and dimerization interface. One of them, phosphorylation occurring in serine at position 51, has been shown to play an important role in 1,25(OH)2D-dependent transcriptional activation. Mutation of this serine residue to glycine stopped the 1,25(OH)2D-induced the phosphorylation process and reduced VDR transcriptional activation in the presence of. This mutation did not affect PKC catalyzed phosphorylation of HL-60 Cells and did not significantly alter AF-2 or Dimerization when 1,25(OH2)2D or Cytosolic Calcium was present.
Unliganded vdr has been shown to interact with and stimulate the induction of cWnt genes as well as Sonic hedgehog in keratinocytes. Furthermore, loss of VDR in animals that have been subjected to experiments results in hair follicle abnormalities including hair loss. Many studies have attempted correlation of RFLPs with specific RFLPs or single nucleotide changes within or around the VDR genes, with clinical phenotypes. However, these studies have only yielded modest insights into the relationship between the expression of genes and clinical disease.